CL-82198 ent antioxidant with anticancer activities LEE-011 succinate

LEE-011 succinate

2007 Feb 16

and 10 (IC50 > 100 µM)

4)17(21)22/h7

and RAD140 also has good bioavailability in rats (F = 27-63%) and monkeys (65-75%)

CL-82198 ent antioxidant with anticancer activities LEE-011 succinateCL 82198 is a selective inhibitor of MMP 13. CL 82198 binds to the entire S1 pocket of MMP 13, which is the basis for its selectivity towards MMP 13 and the lack of inhibitory activities against other MMPs. CL 82198 is a pharmacologic treatment for preventing osteoarthritis (OA) progression. Product information CAS Number: 307002 71 7 Molecular Weight: 338. 83 Formula: C17H23ClN2O3 Chemical Name: N [4 (morpholin 4 yl)butyl] 1 benzofuran 2 carboxamide