Sulbactam Catalog No.:M8108-2 TLR1 inhibits IL-1β-induced phosphorylation of

TLR1 inhibits IL-1β-induced phosphorylation of the mitogen-activated protein kinase p38 in EL4 thymoma cells and in freshly isolated murine lymphocytes in a concentration-dependent manner

PubMed PMID: 21957150

4-oxadiazol-2-yl]cyclobutyl)-3-phenyl-1

Smiles: CS(=O)C1C=CC(=CC=1)C1NC(=C(N=1)C1C=CC(F)=CC=1)C1C=CN=CC=1

Approximately 26-32% of the iv dose of PF-06282999 is excreted in the unchanged form in rat

Sulbactam Catalog No.:M8108-2 TLR1 inhibits IL-1β-induced phosphorylation ofSulbactam, also known as CP 45899, is a lactamase inhibitor. This drug is given in combination with lactam antibiotics to inhibit lactamase, an enzyme produced by bacteria that destroys the antibiotics. Sulbactam is an irreversible inhibitor of lactamase; it binds to the enzyme and does not allow it to degrade the antibiotic. Sulbactam is able to inhibit the most common forms of lactamase but is not able to interact with the AmpC cephalosporinase.