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isolated from Streptomyces cinnamonensis
Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis
TRIM24/TIF1α
1159/000356656
InChi: InChI=1S/C24H28O7/c1-12(2)6-7-13-15(25)10-18-20(21(13)27)22(28)19-14(8-9-24(3
Methyl protodioscin chalcone E isolated from Streptomyces cinnamonensisMethyl protodioscin(NSC 698790) is a furostanol bisglycoside with antitumor properties; shows to reduce proliferation, cause cell cycle arrest. IC50 value: Target: in vitro: MPD showed growth inhibitory effects in A549 cells in a dose and time dependent manner. The significant G2 M cell cycle arrest and apoptotic effect were also seen in A549 cells treated with MPD. MPD induced apoptosis was accompanied by a significant reduction of mitochondrial
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