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5-difluorophenyl)sulfonyl)benzyl)imidazo[1
InChi: InChI=1S/C12H8N4O6S/c13-23(21
CAS Number: 1168091-68-6
resulting in activation of tumor suppressor pathways and concurrent inhibition of several oncogenic pathways
Recent Pat CNS Drug Discov
PJ34 - CAS# 344458-19-1 e O-desmethyl Mebeverine acid 5-difluorophenyl)sulfonyl)benzyl)imidazo[1PJ 34 is a novel and potent PARP 1 inhibitor with potential anticancer activity. PJ34 has a high affinity for PARP 1 (IC(50) = 20 nM). PJ 34 inhibits PARP 1 expression and ERK phosphorylation in glioma conditioned brain microvascular endothelial cells. PJ 34 reduces mesenteric vascular injury induced by experimental cardiopulmonary bypass with cardiac arrest. PJ 34 reduce cell inflammation and damage that follow PARP 1 overexpression. PJ 34 negatively
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