NI-57 - BRPF Bromodomain Inhibitor. CAS# 1883548-89-7 Catalog No.:M60279-10S 4r)-cyclohexane-1

4r)-cyclohexane-1

and SMARCA2 even at 10 μM

Hammitzsch A

Molecular Weight: 406

overexpressing ABCB1

NI-57 - BRPF Bromodomain Inhibitor. CAS# 1883548-89-7 Catalog No.:M60279-10S 4r)-cyclohexane-1NI 57, CAS No. 1883548 89 7, is a potent and selective inhibitor of the bromodomain of the BRPFs. It binds to BRPF1B with a KD of 31 nM (ITC), to BRPF2 with a KD of 108 nM (ITC) and to BRPF3 KD of 408 nM (ITC). NI 57 is very selective against other non Class IV bromodomains, including the BETs, has minimum 32 fold selectivity against BRD9. It shows accelerated FRAP recovery at 1 M in the BRPF2 FRAP assay preventing binding of full length BRPF2 to