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MK-2048 represents a prototype second-generation integrase strand transfer inhibitor (INSTI) developed with the goal of retaining activity against viruses containing mutations associated with resistance to first-generation INSTIs
2010 Apr 15
Antipyrine
32-17-8-6-5-7-9-17)13-30-15(3)10-27-12-25-18-19(22)23-11-24-20(18)27/h5-9
Toll-like Receptor 5-mediated IL-17C Expression in Intestinal Epithelial Cells Enhances Epithelial Host Defense Against F4 + ETEC Infection
Methylnissolin EP-37440 MK-2048 represents a prototype second-generationMethylnissolin (Astrapterocarpan), isolated from Astragalus membranaceus, inhibits platelet derived growth factor (PDGF) BB induced cell proliferation with an IC50 of 10 M. Methylnissolin inhibits PDGF BB induced phosphorylation of extracellular signal regulated kinase 1 2 (ERIC1 2) mitogen activated protein (MAP) kinase. Methylnissolin inhibits PDGF BB induced vascular smooth muscle cell proliferation by inhibition of the ERK1 2 MAP kinase cascade.
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