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Epub 2009 Sep 10
T D Oglesby
in human colon cancer cells
TPPB could increase the phosphorylation of Akt
because its metabolites offer an alternative pathway to the urea cycle to allow excretion of excess nitrogen
Bendamustine Hydrochloride ntan Hydrochloride Epub 2009 Sep 10Bendamustine is a bifunctional mechlorethamine derivative with alkylator and antimetabolite activities. Bendamustine possesses three active moieties: an alkylating group; a benzimidazole ring, which may act as a purine analogue; and a butyric acid side chain. Although its exact mechanism of action is unknown, this agent appears to act primarily as an alkylator. Bendamustine metabolites alkylate and crosslink macromolecules, resulting in DNA, RNA and
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