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Jackman KA
5 μM and a peak activity at 10-20 μM
CAS Number: 1675201-83-8
P53 and Bcl-2 expression
7 and 110 fold selectivity compared to wt-RET and KDR
APX-115 free base - CAS# 1270084-92-8 size:10mg solid Jackman KAAPX 115 free base, CAS No. 1270084 92 8, also known as EWHA 18278, is a potent, orally active pan NADPH oxidase (Nox) inhibitor. APX 115 protects development of diabetic nephropathy in podocyte specific NOX5 transgenic mice. APX 115 might be a promising therapeutic agent for the treatment of DN because of its pan NOX inhibitory activity, including its NOX5 inhibitory activity, and also owing to its anti inflammatory effect. Product information CAS
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