D-α-Hydroxyglutaric acid odesine Smiles: CC1C=C(C(=CC=1)N1N=CC=N1)C(=O)N1CCN(CC[C@H]1C)C1=NC2=CC(Cl)=CC=C2O1

Smiles: CC1C=C(C(=CC=1)N1N=CC=N1)C(=O)N1CCN(CC[C@H]1C)C1=NC2=CC(Cl)=CC=C2O1

psoriatic arthritis) where it has a beneficial effect

it strongly induced the filamentation in B

is an apoptosis inducer

3-dihydro-1H-inden- 1-yl]-1

D-α-Hydroxyglutaric acid odesine Smiles: CC1C=C(C(=CC=1)N1N=CC=N1)C(=O)N1CCN(CC[C@H]1C)C1=NC2=CC(Cl)=CC=C2O1D Hydroxyglutaric acid ((R) 2 Hydroxyglutarate) is the principal metabolite accumulating in neurometabolic disease D 2 hydroxyglutaric aciduria. D Hydroxyglutaric acid is a weak competitive antagonist of ketoglutarate ( KG) and inhibits multiple KG dependent dioxygenases with a Ki of 10. 87 mM. D Hydroxyglutaric acid increases reactive oxygen species (ROS) production. D Hydroxyglutaric acid binds and inhibits ATP synthase and inhibits mTOR signaling.