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Sidrauski C
PubMed PMID: 29299164
1042/BJ20150658
Chemical Name: N-(cyclopropylmethyl)-2-(4-(4-methoxybenzoyl)piperidin-1-yl)-N-((4-oxo-3
6(4):699-706
PF-04929113 free base sgenin Sidrauski CPF 04929113, also known as SNX 5422; is a synthetic prodrug targeting the human heat shock protein 90 (Hsp90) with potential antineoplastic activity. Although the mechanism of action remains to be fully elucidated, Hsp90 inhibitor SNX 5542 is rapidly converted to SNX 2112, which accumulates in tumors relative to normal tissues. SNX 2112 inhibits Hsp90, which may result in the proteasomal degradation of oncogenic client proteins, including HER2 ERBB2,
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