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3Caffeoylquinate
Smiles: CO[C@@H]1C[C@@H](O[C@@H](C)[C@@H]1O)O[C@H]1[C@@H](C)C=CC=C2CO[C@@H]3/C(=N\O)/C(C)=C[C@@H](C(=O)O[C@H]4C[C@H](CC=C1C)O[C@]1(C4)CC[C@H](C)[C@H](O1)C1CCCCC1)[C@@]23O |c:17
PubMed Central PMCID: PMC4421799
(2015) J Immunol
Formula: C20H23N3O8
TW-37 Catalog No.:M7872-2 3CaffeoylquinateTW 37 is a small molecule inhibitor of Bcl 2 family proteins, inhibited cell growth and induced apoptosis in pancreatic cancer. TW 37 induces cell growth inhibition and S phase cell cycle arrest, with regulation of several important cell cycle related genes like p27, p57, E2F 1, cdc25A, CDK4, cyclin A, cyclin D1, and cyclin E. The cell growth inhibition was accompanied by increased apoptosis with concomitant attenuation of Notch 1, Jagged 1, and its