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as well as many other biological processes involving SIRT1
CAS Number: 1675201-83-8
Molecular modeling studies of the novel inhibitors of DNA methyltransferases SGI-1027 and CBC12: implications for the mechanism of inhibition of DNMTs
is a potent and selective ubiquitin-specific protease 7 (USP7) inhibitor with IC50 ~424 nM
(2013) MBio
PP242 - mTORC1/mTORC2 inhibitor. CAS# 1092351-67-1 size:2 mg solid as well as many otherPP242, CAS No. 1092351 67 1, is a highly potent, selective and ATP competitive mTORC1 mTORC2 inhibitor (IC50 = 8 nM). It has > 10 folds selectivity over the other PI 3K family kinases (IC50 0. 102 M, 0. 408 M, 1. 27 M, 1. 96 M and 2. 2 M for p110, DNA PK, p110, p110 and p110, respectively). Except some weak inhibitory activity against PKC, JAK2, PKCI, PKCII and RET (0. 05 0. 22 M), PP242 exhibits excellent selectivity over 215 other protein kinases.
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