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14bS)-3-(acetyloxy)-4
Mangiferin suppresses nuclear translocation of the NF-κB subunits p65 and p50
Liarozole dihydrochloride inhibits the cytochrome P450 (CYP26)-dependent 4-hydroxylation of RA (IC50=7 μM)
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2)10-17(24)19(14)20/h9
MIRA-1 idinium bromide 14bS)-3-(acetyloxy)-4MIRA 1 is a maleimide derived small molecule that reactivates the tumor suppressor function of mutant p53, inducing apoptosis in several human solid tumor cell lines carrying tetracycline regulated mutant p53 (IC50 = 10 M in vitro). 1 Treatment of tumor cells with MIRA 1 induces p21, MDM2 and PUMA in a mutant p53 dependent manner. At a concentration of 5 10 mg kg, MIRA 1, alone or in combination with dexamethasone , arrested tumor growth in a mouse
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