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PubMed PMID: 24179414
Mol Cancer Ther
Solubility: Soluble in DMSO (up to 25mg/mL)
inhibition of DNA repair
Antibacterial activity of tannins isolated from Sapium baccatum extract and use for control of tomato bacterial wilt
ETP-46321 Size:Solid 10 mg PubMed PMID: 24179414ETP 46321 is a potent and orally bioavailable PI3K , inhibitor with potent biochemical and cellular activity and good pharmacokinetic properties (PK) after oral dosing. ETP 46321 PK PD studies showed time dependent downregulation of AKT(Ser473) phosphorylation, which correlates with compound levels in tumor tissue and demonstrating to be efficacious in a GEMM mouse tumor model driven by a K Ras(G12V) oncogenic mutation. Treatment with ETP 46321