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is a potent inhibitor of PERK with an IC50 of 5 nM
PubMed PMID: 17962474
AC-55541 was stable to metabolism by liver microsomes and maintained sustained exposure in rats
also known as L-Gly-7-Amino-4-Methylcoumarin
Smiles: OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O
EBE-A22 Catalog No.:M10416-10 is a potent inhibitor ofEBE A22 is a derivative of PD 153035. EBE A22, has no effect on EGF R TK but maintains a high cytotoxic profile. EBE A22 binds to DNA and behave as typical intercalating agents. EBE A22 unwinds supercoiled plasmid, stabilizes duplex DNA against heat denaturation, and produces negative CD and ELD signals, as expected for an intercalating agent. EBE A22, but not PD153035, interacts preferentially with GC rich sequences and discriminates against
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