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VU6005649 is a CNS penetrant mGlu7/8 receptor agonist with EC50s of 0
InChiKey: HZASIAXCPXTISQ-NVXWUHKLSA-N
Formula: C24H36N6O2
infarct size is reduced by 35% (P=0
is a potent and orally active SHP-1 (PTPN6) agonist
Orexin 2 Receptor Agonist Size:Contact [email protected] for quotation VU6005649 is a CNS penetrantOrexin 2 Receptor Agonist is a potent (EC50 on OX2R is 23 nM) and OX2R selective (OX1R OX2R EC50 ratio is 70) agonist. IC50 value: 23 nM (EC50)Target: Orexin 2 ReceptorOrexin 2 Receptor Agonist shows not only potentactivity but also high selectivity for OX2R over OX1R. In CHO cells overexpressing hOX1R and HEK 293 cells overexpressing hOX2R, compound 26 displaced [125I]orexin A in a concentration dependent manner: 26 bound to hOX2R and hOX1R with Ki
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