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3b-Hydroxy-5-cholenoic acid is a monohydroxy bile acid of endogenous origin and could be found in children with the syndrome of hepatic ductular hypoplasia
1]nonan-3-yl]-1H-indazole-3-carboxamide
InChi: InChI=1S/C21H24ClFN4O3
ClH/c19-7-2-8-20-14(25)9-21-11-4-1-3-10-15(11)18(28)23(17(10)27)12-5-6-13(24)22-16(12)26
23(7):1929-1934
Piboserod hydrochloride o-PEG4-C2-N3 3b-Hydroxy-5-cholenoic acid is a monohydroxyPiboserod (SB 207266) Hcl is a selective 5 HT(4) receptor antagonist. IC50 value: Target: 5 HT4 antagonistin vitro: Piboserod did not modify the basal contractions but concentration dependently antagonized the ability of 5 HT to enhance bladder strip contractions to EFS. In presence of 1 and 100 nM of piboserod, the maximal 5 HT induced potentiations were reduced to 45. 0+ 7. 9 and 38. 7+ 8. 7%, respectively . in vivo: Piboserod significantly