AG-636 217903 selective and reversible fatty acid

selective and reversible fatty acid amide hydrolase (FAAH) inhibitor

3-dimethyl-1-oxobutan-2-yl)amino)-3-oxopropoxy)propoxy)propoxy)-6-methoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1

Smiles: CC(=O)O[C@]12[C@H]3[C@@H](OC(=O)C4C=CC=CC=4)[C@](O)(C[C@H]3C34[C@@H]5[C@@H](OC)C1C3N(C[C@@]5(CC[C@@H]4OC)COC)CC)[C@@H](OC)[C@@H]2O

9-tetramethyldocosahydrospiro[naphtho[2'

SB-743921 (0

AG-636 217903 selective and reversible fatty acidAG 636 is a potent, reversible, selective and orally active dihydroorotate dehydrogenase (DHODH) inhibitor with an IC50 of 17 nM. Differential AG 636 activity translated to the in vivo setting, with complete tumor regression observed in a lymphoma model. Dissection of the relationship between uridine availability and response to AG 636 revealed a divergent ability of lymphoma and solid tumor cell lines to survive and grow in the setting of depleted