MI-136 omide-NH-PEG2-C2-NH-Boc CCT 241533 dihydrochloride inhibits Chk2

CCT 241533 dihydrochloride inhibits Chk2 activation in response to etoposide-induced DNA damage in HT29 cells and blocks ionizing radiation-induced apoptosis of mouse thymocytes

H2O/c1-20-19-28-26(30-21-10-12-23(13-11-21)36-17-16-33-14-5-6-15-33)31-25(20)29-22-8-7-9-24(18-22)37(34

a potent antiviral effect was observed with a significant reduction in viral load and symptoms compared to placebo

ClH/c1-22(2)11-12-26-17-8-5-15(6-9-17)14-21-20(23)16-7-10-18(24-3)19(13-16)25-4

InChi: InChI=1S/C19H19N3O3/c1-13(2)22-16(8-10-21-22)19-14(5-4-9-20-19)12-25-18-7-3-6-17(24)15(18)11-23/h3-11

MI-136 omide-NH-PEG2-C2-NH-Boc CCT 241533 dihydrochloride inhibits Chk2MI 136 is an inhibitor of the menin MLL protein protein interaction (PPI), with an IC50 of 31 nM and a Kd of 23. 6 nM. MI 136 shows to block AR signaling and has the potential for the study in castration resistant tumors. Product information CAS Number: 1628316 74 4 Molecular Weight: 470. 51 Formula: C23H21F3N6S Chemical Name: 5 [(4 {[6 (2,2,2 trifluoroethyl)thieno[2,3 d]pyrimidin 4 yl]amino}piperidin 1 yl)methyl] 1H indole 2 carbonitrile Smiles: