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117(6):1938-46
587841-73-4
Comp Biochem Physiol C Toxicol Pharmacol
Functional proteomics strategy for validation of protein kinase inhibitors reveals new targets for a TBB-derived inhibitor of protein kinase CK2
Molecular Weight: 391
Entrectinib - CAS# 1108743-60-7 size:10mg solid 117(6):1938-46Entrectinib, CAS No. 1108743 60 7, also known as RXDX 101 and NMS E628, is an oral small molecule inhibitor of TrkA, TrkB and TrkC, as well as ROS1 and ALK, with high potency and selectivity. RXDX 101 has demonstrated potent pharmacological activity in preclinical studies and has the potential to be first in class against the Trk family of kinases. PXDX 101 has been well tolerated in patients with advanced solid tumors. PXDX 101 is currently in
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