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GGTI-298 TFA - CAS# 1217457-86-7 60002 but highly potent against ROCK1

SKU: 22141009439

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Description

but highly potent against ROCK1 (IC50=100 nM)

regimen of Narciclasine at 1 mg/kg significantly (P=0

CUDC-907 was orally dosed to mice at 100 mg/kg or intravenously dosed at 50 mg/kg once per day in the xenograft tumor model of SU-DHL4 (DLBCL) and A549 (NSCLC)

S-adenosylmethionine

plays a key role in tumor cell proliferation and tumor vascularization

GGTI-298 TFA - CAS# 1217457-86-7 60002 but highly potent against ROCK1GGTI 298 TFA, CAS No. 1217457 86 7, is a potent geranylgeranyltransferase I (GGTase I) inhibitor with potential antitumor actrivity. GGTI 298 disrupts MAP kinase activation and G(1) S transition in Ki Ras overexpressing transformed adrenocortical cells. GGTI 298 induces hypophosphorylation of retinoblastoma and partner switching of cyclin dependent kinase inhibitors. A potential mechanism for GGTI 298 antitumor activity. GGTI 298 arrests human tumor

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