Torin 1 - CAS# 1222998-36-8 Catalog No.:M6633-2 Smiles: CN1CCC[C@@H](C1)COC1=CC(=CC2CN(CCOC=21)C(=O)CC)C1=CC(OC)=C(C=C1)OC

Smiles: CN1CCC[C@@H](C1)COC1=CC(=CC2CN(CCOC=21)C(=O)CC)C1=CC(OC)=C(C=C1)OC

4 nM for rodent GPR39

Am J Physiol Endocrinol Metab

thermolysin and elastase with Kis of 0

3-benzoxadiazol-7-amine

Torin 1 - CAS# 1222998-36-8 Catalog No.:M6633-2 Smiles: CN1CCC[C@@H](C1)COC1=CC(=CC2CN(CCOC=21)C(=O)CC)C1=CC(OC)=C(C=C1)OCTorin 1, CAS No. 1222998 36 8, is a potent and selective mTOR inhibitor. The apoptosis inducing mTOR inhibitor Torin 1 hindered growth, motility, invasion, and survival of CoCSCs in vitro, and suppressed tumor growth in vivo with a concomitant reduction in vessel formation. Torin 1 also affected the expression of markers for cell proliferation, angio lympho genesis, and stemness in vivo, including Ki67, DLL1, DLL4, Notch, Lgr5, and CD44. Importantly,