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nondepolarizing properties and lack of cardiovascular side effects
N106 directly activates the SUMO-activating enzyme
with low cytotoxicity (SI =2088)
Inhibition was competitive with respect to ATP (Ki = 95 nM)
54(12):4247-63
Siramesine Hydrochloride Catalog No.:M8962-10 nondepolarizing properties and lack ofSiramesine, also known as Lu 28 179, is a potent sigma 2 receptor agonist. Siramesine triggers cell death through destabilisation of mitochondria, but not lysosomes. Siramesine is a lysosomotropic detergent that induces cytoprotective autophagosome accumulation. Siramesine involves lysosomal leakage and oxidative stress. Product information CAS Number: 224177 60 0 Molecular Weight: 491. 04 Formula: C30H32ClFN2O Synonym: Lu 28 179 hydrochloride
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