E-7050 aphazoline Hydrochloride InChi: InChI=1S/C18H28N2O4

InChi: InChI=1S/C18H28N2O4

InChi: InChI=1S/C23H28O11/c1-21-8-13(25)12-7-23(21

A 100-fold higher concentration (2–8 μM) of E6446 was required to inhibit TLR7/8 activated by the imidazoquinoline compound R848

and also to prevent phosphorylation of Smad2/3 and the growth inhibition induced by TGF-beta

InChi: InChI=1S/C56H87NO16/c1-33-17-13-12-14-18-34(2)45(68-9)29-41-22-20-39(7)56(67

E-7050 aphazoline Hydrochloride InChi: InChI=1S/C18H28N2O4Golvatinib, also known as E7050, is an orally bioavailable dual kinase inhibitor of c Met (hepatocyte growth factor receptor) and VEGFR 2 (vascular endothelial growth factor receptor 2) tyrosine kinases with potential antineoplastic activity. c Met VEGFR kinase inhibitor E7050 binds to and inhibits the activities of both c Met and VEGFR 2, which may inhibit tumor cell growth and survival of tumor cells that overexpress these receptor tyrosine kinases.