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a novel transforming growth factor beta receptor type I and type II dual inhibitor
InChi: InChI=1S/C17H28N4O3/c1-5-21(10-9-20(3)4)16(22)13-18-12-15-11-14(7-8-19-15)17(23)24-6-2/h7-8
PMID: 19696185
1 µM final concentration in vitro and in cellular assays
A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity
BMS-708163 (Avagacestat) - γ-Secretase Inhibitor. CAS# 1146699-66-2 B-PNP a novel transforming growth factorBMS 708163 (Avagacestat), CAS No. 1146699 66 2, is a potent, selective and orally bioavailable secretase inhibitor with an IC50 of 0. 3 nM for APP cleavage. It is 190 fold more selective for APP than Notch, having an IC50 of 58 nM for Notch. Phase I clinical trial studies showed that in humans, BMS 708163 decreased CSF A40 and A42 approximately 30% following daily dose of 100 mg after 28 days and by 60% at daily dose of 150 mg. Product information CAS
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