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and MALME-3M cells expressing oncogenic B-RafV600E
It binds CBP and p300 bromodomains directly
Patsharaporn T Sarasombath
14H2/t21-/m1/s1
L-2HG) is an epigenetic modifier and a putative oncometabolite in kidney cancer that inhibits histone demethylases and hence promotes histone methylation
MSA 2 Catalog No.:M7585-10 and MALME-3M cells expressing oncogenicMSA 2 is a non nucleotide STING agonist. It exhibits antitumor activity and stimulates interferon secretion in tumors. MSA 2 induces tumor regression with durable antitumor immunity, and synergizes with anti PD 1 in syngeneic mouse tumor models. It is also orally bioavailable. Non nucleotide STING agonist (EC50 values are 8. 3 and 24 M for human STING isoforms WT and HAQ, respectively). Exhibits antitumor activity and stimulates interferon secretion
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