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Vigabatrin hydrochloride (γ-Vinyl-GABA hydrochloride)
Effects of a newly synthesized K+ channel opener
thereby decreasing cardiac output and myocardial oxygen demands
Solubility: DMSO 10 mg/mL (30
Synthesis and biological evaluation of 3-substituted 2-oxindole derivatives as new glycogen synthase kinase 3β inhibitors
Sulindac sulfone Size:Contact [email protected] for quotation Vigabatrin hydrochloride (γ-Vinyl-GABA hydrochloride)Sulindac sulfone is a metabolite of the nonsteroidal anti inflammatory drug (NSAID) sulindac. In vitro: Sulindac sulfone treatment also inhibited PGE2 production by HCA 7 cells with an IC50 of 360 mmol L. Sulindac sulfone at 100 mmol L reduced 6 ketoPGF by 29. 2%. Sulindac sulfone reduced the colony number of HCA 7 and HCT 116 with an EC50 of 50 mmol l. Sulindac sulfone significantly decreased the expression of total cellular catenin (50% of control),