JIB-04 (NSC693627) - Jumonji Histone Demethylase Inhibitor. CAS# 199596-05-9 0156 Smiles: CC1C=CC(=CC=1)S(=O)(=O)OCC(=O)NC1=CC(O)=C(C=C1)C(O)=O

Smiles: CC1C=CC(=CC=1)S(=O)(=O)OCC(=O)NC1=CC(O)=C(C=C1)C(O)=O

(E)-N-(2-aminophenyl)-3-(1-((4-(1-methyl-1H-pyrazol-4-yl)phenyl)sulfonyl)-1H-pyrrol-3-yl)acrylamide 4-methylbenzenesulfonate

Abstract 966: Predictive biomarkers of the AKT inhibitor

MEK162 (ARRY-162)

Incubation of exponentially growing RaH3 and RaH5 with 1 μM canertinib accumulated the cells in the G1-phase of the cell cycle within 24 h of treatment without induction of apoptosis

JIB-04 (NSC693627) - Jumonji Histone Demethylase Inhibitor. CAS# 199596-05-9 0156 Smiles: CC1C=CC(=CC=1)S(=O)(=O)OCC(=O)NC1=CC(O)=C(C=C1)C(O)=OJIB 04 (NSC693627, E isomer), CAS No. 199596 05 9, is a potent, selective and cell permeable Jumonji histone demethylase inhibitor. Unlike the other known inhibitors, JIB 04 is not a competitive inhibitor of a ketoglutarate. It inhibits the demethylase activity of Jumonji enzymes in vitro, with IC50 ~230 nM for JARID1A (KDM5A), ~440 nM for JMJD2A (KDM4A) and JMJD2B (KDM4B), ~340 nM for JMJD2E (KDM2E), and ~1 M for JMJD3 (KDM6B) and JMJD2C (KDM4C). JIB