PFI-3 - SMARCA Bromodomains Inhibitor. CAS# 1819363-80-8 Catalog No.:M60175-10S A notable feature of ML323

A notable feature of ML323 is that it simultaneously targets two major DNA damage response pathways (TLS and FA) by inhibiting a common deubiquitinase

Chemical Name: ethyl 3-((6-(4

Chemical Name: N-(4-((3-Chloro-4-fluorophenyl)amino)-7-(3-(morpholin-4-yl)propoxy)quinazolin-6-yl)prop-2-enamide dihydrochloride

Atglistatin was used at 10 μM final concentration in vitro and in cellular assays

Smiles: CN1CCN(CC1)C1CCN(CC1)C1=CC(OC)=C(C=C1)NC1=NC(NC2=CC=CC=C2S(=O)(=O)C(C)C)=C(Cl)C=N1

PFI-3 - SMARCA Bromodomains Inhibitor. CAS# 1819363-80-8 Catalog No.:M60175-10S A notable feature of ML323PFI 3, CAS No. 1819363 80 8, is a novel potent, selective and cell permeable inhibitor of SMARCA4 and PB1(5) bromodomains with IC50 ~ 89 nM and 48 nM respectively. It also inhibits SMARCA2, but has no interaction with the other sub family branches including PB1(2 4) and a kinase panel of 36 kinases. It accelerates FRAP recovery in cells at a concentration of 1 M. The SWI SNF related, Matrix associated, Actin dependent Regulator of Chromatin (SMARC)