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initiating β-catenin and Ras degradation through enhancement of the β-catenin destruction complex activating GSK3β
Formula: C39H65N5O8
but not the leukotriene D4-induced bronchoconstriction
GW 791343 also reduces maximal responses to ATP and BzATP in sucrose buffer
27)28/h2-15H
PHA-793887 )hydrazono)butane-1 3-dione initiating β-catenin and Ras degradationPHA 793887 is an inhibitor of multiple cyclin dependent kinases (CDK) with activity against CDK2, CDK1 and CDK4. PHA 793887 was cytotoxic for leukemic cell lines in vitro, with IC(50) ranging from 0. 3 to 7 microM. In colony assays PHA 793887 showed very high activity against leukemia cell lines, with an IC(50) <0. 1 microM indicating that it has efficient and prolonged antiproliferative activity. PHA 793887 induced cell cycle arrest, inhibited Rb and
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