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Balicatib(AAE-581)
79 µM respectively
stem cell renewal and cancer growth
108(14):5620-5
Formula: C22H26N4O3
CUDC-907 - PI3K/HDAC dual inhibitor. CAS# 1339928-25-4 size:2mg solid Balicatib(AAE-581)CUDC 907, CAS No. 1339928 25 4, is a potent inhibitor of class I PI3K kinases with an IC50 of 19 nM, 54 nM, 311 nM and 39 nM for PI3K, PI3K, PI3K and PI3K. It also potently inhibits HDAC1, HDAC2, HDAC3, HDAC6, HDAC10 and HDAC11 with IC50 of 1. 7 nM, 5 nM, 1. 8 nM, 27 nM, 2. 8 nM and 5. 4 nM respectively. Through its simultaneous HDAC inhibitory activity, CUDC 907 durably inhibits the PI3K AKT mTOR pathway and compensatory signaling molecules such as
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