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2-d]pyrimidin-6-yl]methyl]piperidin-4-yl]propan-2-ol
with an IC50 of 92 nM
and inhibits the increases in swiprosin-1 in HRGECs incubated with HG
N-[4-({3-chloro-4-[(3-fluorophenyl)methoxy]phenyl}amino)quinazolin-6-yl]prop-2-enamide
CAS Number: 27741-01-1
A 438079 417 2-d]pyrimidin-6-yl]methyl]piperidin-4-yl]propan-2-olA 438079 is a P2X7 receptor antagonist. A438079 protects against acetaminophen induced liver injury by inhibiting p450 isoenzymes, not by inflammasome activation. A 438079 partially but significantly prevented the 6 OHDA induced depletion of striatal DA stores. P2X7R inhibitor A 438079 reduced electrographic and clinical seizure severity during status epilepticus and reduced seizure induced neuronal death in the neocortex. Blockade of P2X(7) receptors
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