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It suppresses the production of proinflammatory proteins by macrophages and blocks acute inflammation
including initiation of protein synthesis
InChi: InChI=1S/C29H31F3N6O3/c1-37-10-12-38(13-11-37)17-21-6-7-22(15-24(21)29(30
and is positively regulated by myc and strongly expressed in many tumors and tumor cell lines
Fenretinide (1 microM) significantly inhibits OVCAR-5 invasion after 3 days preincubation
GNE-617 - CAS# 1362154-70-8 60100 It suppresses the production ofGNE 617, CAS No. 1362154 70 8, is a potent nicotinamide phosphoribosyltransferase (NAMPT) inhibitor with IC50 value of 5nM. Prolonged inhibition of nicotinamide phosphoribosyltransferase (NAMPT) is a strategy for targeting cancer metabolism. Product information CAS Number: 1362154 70 8 Molecular Weight: 427. 42 Formula: C21H15F2N3O3S Synonym: GNE 617 GNE 617 GNE617 Chemical Name: N (4 ((3,5 difluorophenyl)sulfonyl)benzyl)imidazo[1,2 a]pyridine 6