AT-101 )-N2 N2-dimethyl-N1-(pyridin-2-yl)ethane-1 2-diamine hydrochloride 10(12):1667-1673

10(12):1667-1673

INCB028050 inhibits intracellular signaling of multiple proinflammatory cytokines including IL-6 and IL-23 at concentrations <50 nM

and increases the protein levels of pSMAD2

Docherty KF

Tardiff DF

AT-101 )-N2 N2-dimethyl-N1-(pyridin-2-yl)ethane-1 2-diamine hydrochloride 10(12):1667-1673AT 101 is a small molecule inhibitor of Bcl 2 Bcl xL Mcl 1 that potently induces apoptosis in various cancer cell lines. Product information CAS Number: 90141 22 3 Molecular Weight: 518. 55 Formula: C30H30O8 Synonym: Cottonseed Meal Toxin Gossypol BL 193 BL 193 BL193 NSC 56817 NSC 624336 Pogosin (R) ( ) Gossypol R ( ) gossypol acetic acid AT 101 AT101 Related CAS Number: 12542 36 8 (Gossypol acetic acid) 303 45 7 (Gossypol(RS)) Chemical Name: [2, 2'