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Jirouta Kitagaki
Pyrazolinone-piperidine dipeptide growth hormone secretagogues (GHSs)
CAS Number: 82-08-6
In vivo: The upper dose level for once-daily administration of CFI-402257 is between 6 and 6
Chemical Name: N-(6-dodecanoylnaphthalen-2-yl)-N-methylglycine
A-867744 - CAS# 1000279-69-5 terin) Jirouta KitagakiA 867744 is a type II PAM with good potency and selectivity. A 867744 showed acceptable pharmacokinetic profile across species and brain levels sufficient to modulate alpha7 nAChRs. In a rodent model of sensory gating, A 867744 normalized gating deficits. A 867744 represents a novel class of molecules capable of allosteric modulation of the alpha7 nAChRs. A 867744 potentiated acetylcholine (ACh) evoked currents, with an EC(50) value of approximately 1