For starters, you can offset the life loss by having a demon in play, a condition you can fulfill with the other room, Ritual Chamber
If U/G is a midrange Energy deck, lets look at a few variations on combo versions: Creatures (12) Lands (23) 23 Island Spells (25) Engulf the Shore is such a fascinating card to me
Into the Inklands sapphire cards continue this trend by introducing a collection of new cards that take more advantage of the item cards in the game, as well as providing excellent opportunities for card draw, gaining more ink and cards that just have great stats
I would first look out for cards that have strictly better versions of them available
A handful of cards help protect characters or heal their damage, including the Dinglehopper, which can continuously remove a point of damage every turn
It also sees some play in formats like Vintage and Legacy as a stax piece