It's basically cheating (or, more precisely: a color pie break) that lets red decks get rid of problematic cards like enchantments and guarantees that its target gets out of sight and out of mind, but runs the risk of replacing it with something even worse
This involves missions for unlocking every character and fulfilling specific requirements while playing as some characters
If you run rummage or discard abilities, that downside is somewhat mitigated
As we're in the middle of spoiler season, some of these cards may eventually be eclipsed by others - though we're confident each of these has the potential to be impactful in Standard (and some of them beyond!) 10 Nowhere to Run Removal That Sticks Around To Annoy Nowhere to Run has a few things going for it
For instance, both Tidus and Cecil have been revealed as reprints for Thrasios, Triton Hero and Tymna the Weaver respectively
Honorable Mention #2 (#13 Overall) - Response // Resurgence I run this in many of my Commander decks, more so than the next few