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8 µM to 3
InChiKey: MBXPCHYYQRPOOA-UHFFFAOYSA-N
14-5-9-16(23)10-6-14)15-7-11-17(24)12-8-15/h2-12
CAS Number: 1197194-41-4
Chemical Name: methyl N-{1-[2-(5-{4'-[2-(1-{2-[(methoxycarbonyl)amino]-3-methylbutanoyl}pyrrolidin-2-yl)-1H-imidazol-5-yl]-[1
GQ-16 lator 1 8 µM to 3GQ 16 is a novel partial agonist of peroxisome proliferator activated receptor (PPAR) involved in promoting insulin sensitization . PPAR is mainly involved in fat cell differentiation and insulin sensitivity. In vitro: GQ 16 was an effective inhibitor of Cdk5 mediated phosphorylation of PPAR, exhibiting a Ki value of 160 nM. GQ 16 was specific for PPAR and possessed no detectable activity when tested for the ability to activate other PPAR subtypes
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