When you reveal a nonland card during its resolution, its reflexive triggered ability triggers and you pick a target to be dealt damage
So with that interpretation the most iconic cards are: Base Charizard Base Pikachu Base Charmander Ancient Mew Base Mewtwo Base Blastoise Base Venusaur Mewtwo Strikes Back Promos (All 4) Flying Pikachu Mew Movie Promo I know its a fairly boring list, but I think these are the cards your average citizen is most likely to recognise and/or remember from their childhood or their kids childhoods
Overall, there are plenty of ways to disrupt the opponent's hand, and some of them are more permanent, but Iono is the most efficient way of doing so
If it deals 2 or 4 damage and requires a sub par play or even just two mana to remove it you are very happy with things despite being a card down
Soft board wipes are more situational , usually because they impose a limit on the creatures they remove
If something goes wrong, we make it right