As far as board wipes go, we can split them into three tiers, roughly speaking
Siege Smash
Battle your way through the plane of Ikoria with monster-themed mechanics that grow your creatures build your bond and crush your opponents For Fun My personal favorite is a tough pick because I like something about what each deck has to offer
List of Marvel Universe Cards in Marvels Spider-Man Alibou, Ancient Witness Arachnogenesis Arasta of the Endless Web Beast Within Clever Impersonator Comeuppance Counterspell Feed the Swarm Goblin Bombardment Heroic Intervention Hex Hunter's Insight Infernal Grasp Leyline Binding Lorthos, the Tidemaker Mindbreak Trap Mystic Confluence Najeela, the Blade-Blossom Nine Lives Opposition Agent Parallel Lives Path to Exile Ponder Reanimate Relentless Assault Reprieve Rest in Peace Rite of Replication Savage Beating Saw in Half Shock Silkguard Skithiryx, the Blight Dragon Tangle Terminate Thrill of Possibility Traumatize Unexpected Windfall Wedding Ring Winds of Change Where Can You Open Marvel Universe Spider-Man Cards
You need your hate to be well layered to beat Living End, but you need enough normal stuff to stop Temur Crashcades doofy backup plans
You can use this offensively, to temporarily deal with a stax piece or annoying utility creature