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In addition, the presence of polymorphisms in genes encoding drug-metabolizing enzymes (e.g., cytochrome P 450) may result in the accumulation of the drug or its active metabolites and have been implicated as a cofactor in the development of phenytoin-induced severe adverse cutaneous drug reactions (36)

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The star, full name Charlotte Aitchison, 32, is this years most-nominated artist, with her song Guess, featuring US superstar Billie Eilish, taking the gong for song of the year