Calpain Inhibitor II, ALLM 8514-Butanediamine Chemical Name: N-(1-((cyanomethyl)carbamoyl)cyclohexyl)-4-(2-(4-methylpiperazin-1-yl)thiazol-4-yl)benzamide

Chemical Name: N-(1-((cyanomethyl)carbamoyl)cyclohexyl)-4-(2-(4-methylpiperazin-1-yl)thiazol-4-yl)benzamide

MK8722 (MK-8722) is a potent

ReN 1869 dose-dependently reduces the responses with IC50 of 1

a bromodomain and extraterminal inhibitor

InChiKey: OIZSVTOIBNSVOS-UHFFFAOYSA-N

Calpain Inhibitor II, ALLM 8514-Butanediamine Chemical Name: N-(1-((cyanomethyl)carbamoyl)cyclohexyl)-4-(2-(4-methylpiperazin-1-yl)thiazol-4-yl)benzamideCalpain inhibitor II (CPI 2) is a cell permeable inhibitor of calpain I, calpan II, cathepsin L and cathepsin B. Calpain inhibitor II 2 at 50 or 100 M has shown to induce apoptosis in (acute lymphoblastic leukemia) ALL (ALL 1, RS4; 11, and JURKAT) and (non Hodgkins lymphoma) NHL (RAMOS and DAUDI) cell lines, as measured by MC540 single fluorescence. Additionally, studies have shown that neither BTK nor LYN were required for calpain inhibitor II