Consider its card type, any effects that modify when you could cast it (such as flash) and any other effects that stop you from casting it (such as from Meddling Mage's ability) to determine if and when you can do this
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Only then, so you cannot play sorceries or permanents without flash that's another break
Humans has historically employed four-drops in the sideboard to give the deck a little bit of post-sideboard staying power, and I like what Urza and Yawgmoth bring to the table for this purpose
Cutting it from a competitive deck and trying to swap in something else would almost never be recommended because the card is too important to the deck's overall strategy
Diablo has a strong ability that lets you draw cards passively, and even its main set version will probably cost quite a bit for a while on the singles market