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and CDK4 underlies the efficacy of the HSP90 inhibitor XL88
Hoechst 33258 analog 5 is a analog of Hoechst stains
29)/t15-/m1/s1
2017 Jan 3
ML364 (5-20 μM
RG7112 - CAS# 939981-39-2 dine D6 Hydrochloride and CDK4 underlies the efficacyRO5045337, also known as RG7112, is a MDM2 antagonist with potential antineoplastic activity. RO5045337 binds to MDM2, thereby preventing the binding of the MDM2 protein to the transcriptional activation domain of the tumor suppressor protein p53. By preventing this MDM2 p53 interaction, the proteosome mediated enzymatic degradation of p53 is inhibited and the transcriptional activity of p53 is restored, which may result in the restoration of p53