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Smiles: O=C1NC(=O)CN1N=CC1=NC=C(O1)C1C=CC(Br)=CC=1
WDR5-0103 was used at 10 µM final concentration in various in vitro assays
PMID: 22923591
4S)-4-{(2R)-2-[(3S
Bhakta-Guha D
PF-03716556 Size:2mg solid Smiles: O=C1NC(=O)CN1N=CC1=NC=C(O1)C1C=CC(Br)=CC=1PF 03716556 is a potent, and selective acid pump antagonist for the treatment of gastroesophageal reflux disease. PF 03716556 demonstrated 3 fold greater inhibitory activity than revaprazan. PF 03716556 did not display any species differences, exhibiting highly selective profile including the canine kidney Na(+), K(+) ATPase. Kinetics experiments revealed that PF 03716556 has a competitive and reversible mode of action. Product information CAS Number: