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Formula: C28H28ClN3OS
42(3):142-7
which has antitumor activities by inhibition of mitochondrial complex I
Solubility: DMSO up to 100mM
Chemical Name: 2-Hydroxy-1-naphthaldehyde isonicotinoylhydrazone
Verteporfin (Visudyne) - YAP Inhibitor. CAS# 129497-78-5 045 Formula: C28H28ClN3OSVerteporfin (Visudyne), CAS No. 129497 78 5, is a potent and selective YAP inhibitor, disrupts YAP TEAD interactions and enhances trypsin cleavage of YAP with EC50 ~100 nM. It inhibits growth and proliferation of retinoblastoma cells. It also significantly blocks cancer stem cell (CSC) properties in cells with high YAP1 and a high proportion of ALDH1(+). In vivo it can suppress YAP induced liver overgrowth in mice. Product information CAS Number:
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