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Harmston N
Smiles: NC1=NC(Cl)=NC2=C1N=CN2[C@H]1C[C@H](O)[C@@H](CO)O1
17R)-13-Methyl-17-prop-2-enyl-2
2ClH/c23-19(22-9-7-21(8-10-22)18-5-6-18)17-3-1-16(2-4-17)15-20-11-13-24-14-12-20
Formula: C24H34ClN3O9P2
PRX-08066 - CAS# 866206-54-4 411575 (isomer 3) Harmston NPRX 08066 is a a novel 5 hydroxytryptamine receptor 2B antagonist, reduces monocrotaline induced pulmonary arterial hypertension and right ventricular hypertrophy in rats. In the 5 HT(2B) expressing SI NET cell line, KRJ I, PRX 08066 inhibited proliferation (IC(50) 4. 6 x 10( 9)M) and 5 HT secretion (6. 9 x 10( 9)M) and decreased ERK1 2 phosphorylation and profibrotic growth factor synthesis and secretion (transforming growth factor beta 1 [TGFbeta1],
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