MAK-683 - CAS# 1951408-58-4 Catalog No.:M7137-2 is a potent and selective

is a potent and selective inhibitor of heat shock protein 90 (Hsp90) subtypes alpha and beta

Smiles: [O-][N+](=O)C1=CC=C2NC3=C(CC(=O)NC4=CC=CC=C43)C2=C1

apolipoprotein B

PubMed PMID: 25074280

13(23):4525-33

MAK-683 - CAS# 1951408-58-4 Catalog No.:M7137-2 is a potent and selectiveMAK 683, CAS No. 1951408 58 4, is a potent inhibitor of embryonic ectoderm development protein (EED) and allosteric inhibitor of polycomb repressive complex 2 (PRC2), with potential antineoplastic activity. Upon administration, MAK683 selectively binds to the domain of EED that interacts with trimethylated lysine 27 on histone 3 (H3K27me3), which leads to a conformational change in the EED H3K27me3 binding pocket and prevents the interaction of EED