Much like the other cards that make opponents mill half of their deck, Maddening Cacophonys best application is with Bruvac the Grandiloquent, who turns this into a game-winning combo
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Incredibly casual, with a focus on decks built around a theme (like "the Weatherlight Crew") as opposed to focused on winning
During the mid-game, the opponent will be likely to still have a reasonable number of Life cards while also beginning to bring out their heavy hitters
That said, Satoru Umezawa makes for a great Commander on its own, as it gives all creatures in hand ninjutsu for two generic mana, one blue mana, and one black mana
Its no surprise that its the color with some of the most solid and terrifying card draw spells in all of Magic